Attenuated vasodilator effectiveness of protease-activated receptor 2 agonist in heterozygous par2 knockout mice.

Studies of homozygous PAR2 gene knockout mice have described a mix of phenotypic effects in vitro and in vivo.However, there have been few studies of PAR2 heterozygous (wild-type/knockout; PAR2-HET) mice.The phenotypes of many hemi and heterozygous transgenic mice have been described as intermediates between those of wild-type and knockout animals.

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